Development of a thin layer chromatography method for plasma correction of [18F] fluorocholine metabolites in positron emission tomography quantification studies in …
M Villar, M Valiente, M Toscano, M Galmes… - Nuclear Medicine and …, 2019 - Elsevier
Introduction After its intravenous injection,[18 F] fluorocholine is oxidized by choline-oxidase
into its main plasma metabolite,[18 F] fluorobetaine. If PET kinetic modeling quantification of
[18 F] fluorocholine uptake is intended, the plasma input time-activity-curve of the parent
tracer must be obtained, ie, the fraction of the total plasma radioactivity corresponding to the
nonmetabolized [18 F] fluorocholine at each time has to be known. Hence our aim was to
develop an easy-routine Thin-Layer-Chromatography (TLC) method to separate and …
into its main plasma metabolite,[18 F] fluorobetaine. If PET kinetic modeling quantification of
[18 F] fluorocholine uptake is intended, the plasma input time-activity-curve of the parent
tracer must be obtained, ie, the fraction of the total plasma radioactivity corresponding to the
nonmetabolized [18 F] fluorocholine at each time has to be known. Hence our aim was to
develop an easy-routine Thin-Layer-Chromatography (TLC) method to separate and …
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