leaks in an experimental pipeline. A dynamic PCA implementation (DPCA) was used to
capture the process dynamics because the system variables are time-correlated. To detect
leaks online, the Hotelling's T2 statistic and the squared prediction error (SPE) were used as
residuals, which are compared against statistically defined thresholds from a set of training
data. To determine the number of delays to be included in the DPCA model as well as the …