Dnmt3a and Dnmt3b-decommissioned fetal enhancers are linked to kidney disease
Background Cytosine methylation is an epigenetic mark that dictates cell fate and response
to stimuli. The timing and establishment of methylation logic during kidney development
remains unknown. DNA methyltransferase 3a and 3b are the enzymes capable of
establishing de novo methylation. Methods We generated mice with genetic deletion of
Dnmt3a and Dnmt3b in nephron progenitor cells (Six2 Cre Dnmt3a/3b) and kidney tubule
cells (Ksp Cre Dnmt3a/3b). We characterized Ksp Cre Dnmt3a/3b mice at baseline and after …
to stimuli. The timing and establishment of methylation logic during kidney development
remains unknown. DNA methyltransferase 3a and 3b are the enzymes capable of
establishing de novo methylation. Methods We generated mice with genetic deletion of
Dnmt3a and Dnmt3b in nephron progenitor cells (Six2 Cre Dnmt3a/3b) and kidney tubule
cells (Ksp Cre Dnmt3a/3b). We characterized Ksp Cre Dnmt3a/3b mice at baseline and after …
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