Effects of aging on RANKL and OPG levels in gingival crevicular fluid during orthodontic tooth movement
K Kawasaki, T Takahashi… - Orthodontics & …, 2006 - Wiley Online Library
K Kawasaki, T Takahashi, M Yamaguchi, K Kasai
Orthodontics & craniofacial research, 2006•Wiley Online LibraryStructured Abstract Authors–Kawasaki K, Takahashi T, Yamaguchi M, Kasai K Objectives–
To compare the levels of the receptor activator of NFkB ligand (RANKL) and osteoprotegerin
(OPG) in the gingival crevicular fluid (GCF) during orthodontic tooth movement in juvenile
and adult patients. Design–Fifteen juveniles and 15 adults served as subjects. GCF was
collected from the distal cervical margins of the experimental and control teeth at 0, 1, 24,
and 168 h after application of a retracting force. Enzyme‐linked immunosorbent assay kits …
To compare the levels of the receptor activator of NFkB ligand (RANKL) and osteoprotegerin
(OPG) in the gingival crevicular fluid (GCF) during orthodontic tooth movement in juvenile
and adult patients. Design–Fifteen juveniles and 15 adults served as subjects. GCF was
collected from the distal cervical margins of the experimental and control teeth at 0, 1, 24,
and 168 h after application of a retracting force. Enzyme‐linked immunosorbent assay kits …
Structured Abstract
Authors – Kawasaki K, Takahashi T, Yamaguchi M, Kasai K
Objectives – To compare the levels of the receptor activator of NFkB ligand (RANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) during orthodontic tooth movement in juvenile and adult patients.
Design – Fifteen juveniles and 15 adults served as subjects. GCF was collected from the distal cervical margins of the experimental and control teeth at 0, 1, 24, and 168 h after application of a retracting force. Enzyme‐linked immunosorbent assay kits were used to determine RANKL and OPG levels in the GCF samples.
Results – The amount of tooth movement for juveniles was larger than for adults after 168 h. Further, after 24 h RANKL levels were increased and those of OPG decreased in GCF samples from the compression side during orthodontic tooth movement in both juveniles and adults. The RANKL/OPG ratio in GCF from adult patients was lower than that in the juvenile patient samples.
Conclusion – Our results suggest that the age‐related decrease in amount of tooth movement may be related to a decrease in RANKL/OPG ratio in GCF during the early stages of orthodontic tooth movement.
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