haemodynamic measurements, neurohumoral activity, and left-ventricular remodelling when
added to angiotensin-converting-enzyme (ACE) inhibitors in patients with chronic heart
failure (CHF). We aimed to find out whether these drugs improve clinical outcome. Methods
Between March, 1999, and November, 1999, we enrolled 2548 patients with New York
Heart Association functional class II–IV CHF and left-ventricular ejection fraction 40% or …