Conditions under which genome-wide association studies will be positively misleading

A Platt, BJ Vilhjálmsson, M Nordborg - Genetics, 2010 - academic.oup.com
… can be reproduced in independent studies. GENOME-WIDE association mapping is a
powerful … will exhibit significant statistical association with the trait. There are two ways in which …

Autoimmune diseases: insights from genome-wide association studies

G Lettre, JD Rioux - Human molecular genetics, 2008 - academic.oup.com
… Rather, we focus here on how genome-wide association studies (GWAS) have changed
the genetic landscape of CeD, Crohn's disease (CD), MS, RA, SLE and T1D research in less …

Genome-wide association studies of 14 agronomic traits in rice landraces

X Huang, X Wei, T Sang, Q Zhao, Q Feng, Y Zhao… - Nature …, 2010 - nature.com
… We performed genome-wide association studies (GWAS) for 14 agronomic traits in the
population of Oryza sativa indica subspecies. The loci identified through GWAS explained ∼36% …

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

JH Park, S Wacholder, MH Gail, U Peters, KB Jacobs… - Nature …, 2010 - nature.com
genome-wide association studies (GWASs). We propose statistical power calculations for
future GWASs using estimated distributions of effect sizes. Using reported GWAS findings for …

Genomewide association studies provide new insights into type 2 diabetes aetiology

TM Frayling - Nature Reviews Genetics, 2007 - nature.com
Genome-wide association studies (GWAS) promised to greatly enhance our understanding
of the genetic basis of common and complex diseases. Companies such as Affymetrix and …

Risk prediction using genomewide association studies

C Kooperberg, M LeBlanc… - Genetic epidemiology, 2010 - Wiley Online Library
… Over the last few years, many new genetic associations have been identified by genomewide
association studies (GWAS). There are potentially many uses of these identified variants: …

Principal components analysis corrects for stratification in genome-wide association studies

AL Price, NJ Patterson, RM Plenge, ME Weinblatt… - Nature …, 2006 - nature.com
… In addition, our approach is computationally tractable on a genome-wide scale. Here, we
test EIGENSTRAT on simulated genome-wide disease studies and apply it to a real data set of …

Insights into kidney diseases from genome-wide association studies

M Wuttke, A Köttgen - Nature Reviews Nephrology, 2016 - nature.com
… decade, genome-wide association studies (GWAS) have considerably improved our
understanding of the genetic basis of kidney function and disease. Population-based studies, used …

[PDF][PDF] Genome-wide association studies in maize: praise and stargaze

Y Xiao, H Liu, L Wu, M Warburton, J Yan - Molecular plant, 2017 - cell.com
Genome-wide association study (GWAS) has become a widely accepted strategy for
decoding genotypephenotype associations in many species thanks to advances in next-generation …

[HTML][HTML] Estimation of a significance threshold for genome-wide association studies

AS Kaler, LC Purcell - BMC genomics, 2019 - Springer
… Selection of an appropriate statistical significance threshold in genome-wide association
studies is critical to differentiate true positives from false positives and false negatives. Different …