Genotoxicity assessment of drinking water disinfection byproducts by DNA damage and repair pathway profiling analysis
Genotoxicity is considered a major concern for drinking water disinfection byproducts
(DBPs). Of over 700 DBPs identified to date, only a small number has been assessed with
limited information for DBP genotoxicity mechanism (s). In this study, we evaluated
genotoxicity of 20 regulated and unregulated DBPs applying a quantitative toxicogenomics
approach. We used GFP-fused yeast strains that examine protein expression profiling of 38
proteins indicative of all known DNA damage and repair pathways. The toxicogenomics …
(DBPs). Of over 700 DBPs identified to date, only a small number has been assessed with
limited information for DBP genotoxicity mechanism (s). In this study, we evaluated
genotoxicity of 20 regulated and unregulated DBPs applying a quantitative toxicogenomics
approach. We used GFP-fused yeast strains that examine protein expression profiling of 38
proteins indicative of all known DNA damage and repair pathways. The toxicogenomics …
Genotoxicity assessment of drinking water disinfection byproducts by DNA damage and repair pathway profiling analysis.
LJQ Lan JiaQi, SM Rahman, GN Gou Na, JT Jiang Tao… - 2018 - cabidigitallibrary.org
Genotoxicity is considered a major concern for drinking water disinfection byproducts
(DBPs). Of over 700 DBPs identified to date, only a small number has been assessed with
limited information for DBP genotoxicity mechanism (s). In this study, we evaluated
genotoxicity of 20 regulated and unregulated DBPs applying a quantitative toxicogenomics
approach. We used GFP-fused yeast strains that examine protein expression profiling of 38
proteins indicative of all known DNA damage and repair pathways. The toxicogenomics …
(DBPs). Of over 700 DBPs identified to date, only a small number has been assessed with
limited information for DBP genotoxicity mechanism (s). In this study, we evaluated
genotoxicity of 20 regulated and unregulated DBPs applying a quantitative toxicogenomics
approach. We used GFP-fused yeast strains that examine protein expression profiling of 38
proteins indicative of all known DNA damage and repair pathways. The toxicogenomics …
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