the adjacent cells (paracrine) or on their own secreting cells (autocrine)—these ubiquitous
compounds are referred to as autacoids. Histamine and serotonin, the most versatile
autacoids, are involved in the regulation of many of the nervous system, cardiovascular
system, and gastrointestinal system functions. The structure, chemistry, biosynthesis,
metabolism, receptors, and pathophysiological effects of histamine and serotonin are …