[HTML][HTML] Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth
Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best
available examples of the humoral immune response to HIV are providing important
information for the development of therapies and prophylaxis for HIV-1 infection. Here, we
report a CD4-binding site (CD4bs) antibody, named N6, that potently neutralized 98% of HIV-
1 isolates, including 16 of 20 that were resistant to other members of its class. N6 evolved a
mode of recognition such that its binding was not impacted by the loss of individual contacts …
available examples of the humoral immune response to HIV are providing important
information for the development of therapies and prophylaxis for HIV-1 infection. Here, we
report a CD4-binding site (CD4bs) antibody, named N6, that potently neutralized 98% of HIV-
1 isolates, including 16 of 20 that were resistant to other members of its class. N6 evolved a
mode of recognition such that its binding was not impacted by the loss of individual contacts …
Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth.
HJH Huang JingHe, BH Kang, E Ishida… - 2016 - cabidigitallibrary.org
Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best
available examples of the humoral immune response to HIV are providing important
information for the development of therapies and prophylaxis for HIV-1 infection. Here, we
report a CD4-binding site (CD4bs) antibody, named N6, that potently neutralized 98% of HIV-
1 isolates, including 16 of 20 that were resistant to other members of its class. N6 evolved a
mode of recognition such that its binding was not impacted by the loss of individual contacts …
available examples of the humoral immune response to HIV are providing important
information for the development of therapies and prophylaxis for HIV-1 infection. Here, we
report a CD4-binding site (CD4bs) antibody, named N6, that potently neutralized 98% of HIV-
1 isolates, including 16 of 20 that were resistant to other members of its class. N6 evolved a
mode of recognition such that its binding was not impacted by the loss of individual contacts …
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