Mode-dependent effect of low-frequency stimulation targeting the hippocampal CA3 subfield on amygdala-kindled seizures in rats
HL Sun, SH Zhang, K Zhong, ZH Xu, W Zhu, Q Fang… - Epilepsy research, 2010 - Elsevier
Brain stimulation with low-frequency stimulation (LFS) is emerging as an alternative
treatment for refractory epilepsy. The present study aimed to investigate the effects of LFS
targeting the hippocampal CA3 subfield in different modes on amygdala-kindled seizures in
Sprague–Dawley rats. When fully kindled seizures were achieved by daily electrical
stimulation of the amygdala, LFS (15min train of 0.1 ms pulses at 1Hz and 100μA) of the
CA3 was applied in several modes. Post-treatment with LFS significantly reduced the …
treatment for refractory epilepsy. The present study aimed to investigate the effects of LFS
targeting the hippocampal CA3 subfield in different modes on amygdala-kindled seizures in
Sprague–Dawley rats. When fully kindled seizures were achieved by daily electrical
stimulation of the amygdala, LFS (15min train of 0.1 ms pulses at 1Hz and 100μA) of the
CA3 was applied in several modes. Post-treatment with LFS significantly reduced the …
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