Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global
pandemic. Beyond the well-described respiratory manifestations, SARS-CoV-2 may cause a
variety of neurologic complications, including headaches, alteration in taste and smell,
encephalopathy, cerebrovascular disease, myopathy, psychiatric diseases, and ocular
disorders. Herein we describe SARS-CoV-2's mechanism of neuroinvasion and the
epidemiology, outcomes, and treatments for neurologic manifestations of COVID-19.

The Coronavirus disease due to SARS-CoV-2 emerged in Wuhan city, China in December
2019 and rapidly spread to more than 200 countries as a global health pandemic. There are
more than 3.5 million confirmed cases and around 165,000 to 243,000 fatalities. The primary
manifestation is respiratory and cardiac but neurological features are also being reported in
the literature as case reports and case series. The most common reported symptoms to
include headache and dizziness followed by encephalopathy and delirium. Among the …