Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant
Variants of SARS-CoV-2 have become a major public health concern due to increased
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal
antibody therapeutics. The highly transmissible Omicron variant has up to 32 mutations
within the spike protein, many more than previous variants, heightening these concerns of
immune escape. There are now multiple antiviral therapeutics that have received approval
for emergency use by the FDA and target both the SARS-CoV-2 RNA-dependent RNA …
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal
antibody therapeutics. The highly transmissible Omicron variant has up to 32 mutations
within the spike protein, many more than previous variants, heightening these concerns of
immune escape. There are now multiple antiviral therapeutics that have received approval
for emergency use by the FDA and target both the SARS-CoV-2 RNA-dependent RNA …
[PDF][PDF] Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant
V Simon, A García-Sastre, KM White - storage.prod.researchhub.com
Variants of SARS-CoV-2 have become a major public health concern due to increased
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal
antibody therapeutics. The highly transmissible Omicron variant has up to 32 mutations
within the spike protein, many more than previous variants, heightening these concerns of
immune escape. There are now multiple antiviral therapeutics that have received approval
for emergency use by the FDA and target both the SARS-CoV-2 RNA-dependent RNA …
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal
antibody therapeutics. The highly transmissible Omicron variant has up to 32 mutations
within the spike protein, many more than previous variants, heightening these concerns of
immune escape. There are now multiple antiviral therapeutics that have received approval
for emergency use by the FDA and target both the SARS-CoV-2 RNA-dependent RNA …
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