PRC2 directly methylates GATA4 and represses its transcriptional activity
A He, X Shen, Q Ma, J Cao, A von Gise… - Genes & …, 2012 - genesdev.cshlp.org
Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic
gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is
required for cardiac morphogenesis. Both in vitro and in fetal hearts, EZH2 interacted with
cardiac transcription factor GATA4 and directly methylated it at Lys 299. PRC2 methylation of
GATA4 attenuated its transcriptional activity by reducing its interaction with and acetylation …
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic
gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is
required for cardiac morphogenesis. Both in vitro and in fetal hearts, EZH2 interacted with
cardiac transcription factor GATA4 and directly methylated it at Lys 299. PRC2 methylation of
GATA4 attenuated its transcriptional activity by reducing its interaction with and acetylation …
[PDF][PDF] PRC2 directly methylates GATA4 and represses its transcriptional
A He, X Shen, Q Ma - pulab.org
Polycomb-repressive complex 2 (PRC2) promotes tissuespecific differentiation by
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic
gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is
required for cardiac morphogenesis. Both in vitro and in fetal hearts, EZH2 interacted with
cardiac transcription factor GATA4 and directly methylated it at Lys 299. PRC2 methylation of
GATA4 attenuated its transcriptional activity by reducing its interaction with and acetylation …
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic
gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is
required for cardiac morphogenesis. Both in vitro and in fetal hearts, EZH2 interacted with
cardiac transcription factor GATA4 and directly methylated it at Lys 299. PRC2 methylation of
GATA4 attenuated its transcriptional activity by reducing its interaction with and acetylation …
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