Europe is facing a new challenge – namely that of migration, and the negative attitudes stemming from the constant inflow of immigrants. Although France has historic experience with social inclusion and immigration issues, even there, the 2014 regional elections indicated mistrust towards immigrants. Present paper endeavors to analyze the phenomenon from economic, social, political and cultural perspectives based on the data provided by the European Social Survey focusing on the case of France. Research results indicated that trust is an important factor when it comes to attitudes towards immigrants. On the one hand, those, who have lower level of trust in national institutions, such as the police are more afraid of immigrants and of the threats they might pose. On the other hand, mistrust rooted in dissimilarity – like difference in religions – is also significant based on the data displayed in the article.