… to test for increased mRNA expression, including 5′ and 3′ … to their potential to enhance
or fine-tune mRNA translation or … the mRNA stabilized with ψ and a structure-optimized CDS …

… , exogenous mRNA is translated by the ribosomal translation … and optimize more efficient
polymers for enhanced mRNA … in the nanoparticle of stabilizing lipids and PEG, while the …

… that increase the stability and translation of mRNA 30,45 . The stabilizing effect of human
β-… In another strategy, the IVT mRNA was optimized for in situ transfection of DCs in vivo. The …

… the host cell machinery to translate the mRNA encoded target … , stabilize the mRNA, and
mitigate against precipitation of the … (rhesus) with Ab700364 mRNA in optimized Acuitas LNP. …

… The mRNA is susceptible to degradation and stabilizing it … optimization and significant
modifications of the mRNA … , translation capacity and increase the efficacy of mRNA vaccines to …

… three changes: (a) the two stabilizing proline mutations 31 in BNT-162b2 … their superiority
over the commonly used codon-optimization … : chemical stability, protein translation and in vivo …

… contains the coding sequence that is translated into protein. … coding regions, it can be optimized
to increase translation without … core stabilized by a lipid shell that adsorbs mRNA onto its …

… stabilization sequences are usually located at the untranslated (UTR) 3 ∨ end of the mRNA
(… To optimize the production of the desired protein from mRNA molecules, the correct start …

… role in mRNA splicing, stabilization, transport and, most importantly, it facilitates the translation
… Further optimization of the mRNA structure can be done by replacing unstable non-coding …

… (IVT) mRNA functionality and efficacy, including the optimization of its stability and translational
… Besides stabilizing the mRNA in the translation, splicing, polyadenylation and nuclear …