The field of point-of-care (POC) diagnostics offers the tantalizing possibility of providing rapid diagnostic results in nonlaboratory settings. Here, we review progress in this research field, with a focus on developments since 2014. First, we provide an overview of significant technological and social trends, notably those concerning data connectivity, which have shifted the underlying landscape for how POC diagnostic devices will be designed, built, and delivered across different healthcare settings. We review important technical advances in fundamental diagnostic components and, increasingly, advances in fully integrated devices designed for specific clinical use cases. While few new classes of POC diagnostic devices have been introduced into the market, continued progress in microfluidics, combined with dramatic advances in connected devices, is bringing the prospects of fulfilling the lofty promises of POC diagnostics closer than ever to reality. With the rise of connected consumer devices, entire sectors of the economy (including retail, transportation, housing, and freelancing services) have been unmistakably transformed. The potential reach of POC diagnostics into all sectors of healthcare, and increasingly into daily routines of individual patients and consumers, demands that technical advances take into consideration this broader transformation. For healthcare providers, the landscape for medicine is poised for a dramatic shift. In any decentralized setting, a connected POC diagnostic device could be available to aid the diagnosis of disease and selection of treatments. Clay Christiansen, a business theorist, predicts a disruption to the healthcare system,“[Disruption will happen].... in practices where the doctor uses these trends point-of-care imaging and diagnostics, expert systems, telemedicine and personal health records.” 1 With therapeutics becoming increasingly tailored to individuals’ precise genetics and biomarkers, the value chain of healthcare delivery could move up to accurate and accessible POC diagnostics as opposed to therapeutics. For consumers and patients, the impact could be even more dramatic. With the rise of connected consumer electronic devices, patients and consumers are adjusting in how they