DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site
strength in multiple tissues. Pangolin outperforms state-of-the-art methods for predicting
RNA splicing on a variety of prediction tasks. Pangolin improves prediction of the impact of
genetic variants on RNA splicing, including common, rare, and lineage-specific genetic
variation. In addition, Pangolin identifies loss-of-function mutations with high accuracy and …