Multiple, complex molecular events characterize cancer development and progression.
Deciphering the molecular networks that distinguish organ-confined disease from metastatic
disease may lead to the identification of biomarkers of cancer invasion and disease
aggressiveness. Although alterations in gene expression have been extensively quantified
during neoplastic progression, complementary analyses of proteomic changes have been
limited. Here we interrogate the proteomic alterations in a cohort of 15 prostate-derived …

Deciphering the molecular networks that distinguish organ-confined disease from metastatic
disease may lead to the identification of biomarkers of cancer invasion and disease
aggressiveness. Although alterations in gene expression have been extensively quantified
during neoplastic progression, complementary analyses of proteomic changes have been
limited. Here we interrogate the proteomic alterations in a cohort of 15 prostate-derived
tissues that included five each from adjacent benign prostate (Benign), clinically localized …