Large-scale biophysical circuit models provide mechanistic insights into the micro-scale and
macro-scale properties of brain organization that shape complex patterns of spontaneous
brain activity. We developed a spatially heterogeneous large-scale dynamical circuit model
that allowed for variation in local synaptic properties across the human cortex. Here we
show that parameterizing local circuit properties with both anatomical and functional
gradients generates more realistic static and dynamic resting-state functional connectivity …

Spontaneous fluctuations in large-scale brain activity exhibit complex spatiotemporal
patterns across animal species. The fluctuations are thought to arise from the reverberation
of intrinsic dynamics of local brain regions interacting across long-range anatomical
connections. Large-scale biophysical circuit models have provided mechanistic insights into
spontaneous brain activity. However, most previous large-scale circuit models assumed that
local circuit properties are identical across brain regions, which is not biologically plausible …