Qualitative comparative analysis is increasingly applied in strategy and organization research. The main purpose of our essay is to support this growing community of qualitative comparative analysis scholars by identifying best practices that can help guide researchers through the key stages of a qualitative comparative analysis empirical study (model building, sampling, calibration, data analysis, reporting, and interpretation of findings) and by providing examples of such practices drawn from strategy and organization studies. Coupled with this main purpose, we respond to Miller’s essay on configuration research by highlighting our points of agreement regarding his recommendations for configurational research and by addressing some of his concerns regarding qualitative comparative analysis. Our article thus contributes to configurational research by articulating how to leverage qualitative comparative analysis for enriching configurational theories of strategy and organization.