Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular
composition but also in cell-type-specific gene expression in mouse models of kidney
disease. This analysis highlighted major changes in cellular diversity in kidney disease,
which markedly impacted whole-kidney transcriptomics outputs. Cell-type-specific
differential expression analysis identified proximal tubule (PT) cells as the key vulnerable …

Kidney disease is poorly understood because of the organ's cellular diversity. We used
single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular
composition but also in celltype-specific gene expression in mouse models of kidney
disease. This analysis highlighted major changes in cellular diversity in kidney disease,
which markedly impacted whole-kidney transcriptomics outputs. Celltype-specific differential
expression analysis identified proximal tubule (PT) cells as the key vulnerable cell type …