The spread of domestic plants and animals from the Near East towards the Western Mediterranean region is analysed using the current radiocarbon dataset relating to the last hunter-gatherers and the first farmers in the area. In order to do this, we have selected radiocarbon dates and built summed probability distributions and density maps, as a means of investigating the processes involved in the expansion of food production economies throughout this wide territory, in a ‘longue durée’ view, in accordance with a multiscalar approach covering both the general and the regional scenarios. This approach allows us to visualise the time of the expansion in this broad area, starting at the beginning of the sixth millennium cal BC, and to discuss the implied mechanisms in what seems, at least along the coast, a very rapid process: reflecting a mix of demic and cultural models with regional nuances.