Aims Owing to new evidence from randomized controlled trials (RCTs) in low-risk patients
with severe aortic stenosis, we compared the collective safety and efficacy of transcatheter
aortic valve implantation (TAVI) vs. surgical aortic valve replacement (SAVR) across the
entire spectrum of surgical risk patients. Methods and results The meta-analysis is registered
with PROSPERO (CRD42016037273). We identified RCTs comparing TAVI with SAVR in
patients with severe aortic stenosis reporting at different follow-up periods. We extracted …

Aims In view of the currently available evidence from randomized trials, we aimed to
compare the collective safety and efficacy of transcatheter aortic valve implantation (TAVI)
vs. surgical aortic valve replacement (SAVR) across the spectrum of risk and in important
subgroups. Methods and results Trials comparing TAVI vs. SAVR were identified through
Medline, Embase, and Cochrane databases. The primary outcome was death from any
cause at 2 years. We performed random-effects meta-analyses to combine the available …