Residential spatial differentiation is a common phenomenon during the urbanization process of large cities. This paper studies residential differentiation in Hangzhou, China, by combining subdistrict-level (Jie Dao) data from a resident travel survey. After creating 29 demographic and accessibility variables for 74 sub-districts of Hangzhou, a mixed method approach is used to analyze the spatial differentiation of diverse social groups. This approach integrates factor analysis, cluster analysis, and spatial expression. The results show that people of different incomes and occupations show a differentiated choice of living space. High-income groups, middle-income professionals and technicians, and other members of the urban elite prefer to live in the central city. The tendency of suburbanization is not apparent, and new-built gentrification appears in certain emerging urban areas. In addition to accessibility of the central business district and employment concentration, accessibility of neighboring communities and accessibility of quality education resources have also become more prominent impacts on social-spatial differentiation.