donor organs for allotransplantation. In the last two decades, major progress has been made
in understanding the xenoimmunobiology of pig-to-nonhuman primate transplantation, and
today we are close to clinical trials. The ability to genetically engineer pigs, such as human
decay-accelerating factor (hDAF), CD46 (membrane cofactor protein), or α1, 3-
galactosyltransferase gene-knockout (GT-KO), has been a significant step toward the clinical …