[PDF][PDF] Genomewide association studies--illuminating biologic pathways

JN Hirschhorn - New England journal of medicine, 2009 - enigma.ini.usc.edu
… For example, in 2005, two friends and … Society of Human Genetics (ASHG) held its meeting
in the autumn of 2008. During the past 2 years, however, genomewide association studies

Genetic association studies of suicidal behavior: a review of the past 10 years, progress, limitations, and future directions

B Mirkovic, C Laurent, MA Podlipski, T Frebourg… - Frontiers in …, 2016 - frontiersin.org
studies. The aim of this paper is to review recent … association studies in SBs including (i)
case–control studies, (ii) family-based association studies, and (iii) genome-wide association

Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
… A plot of the number of independent or near-independent genome-wide significant loci (P
< 5 × 10 −8 ) reported from genome-wide association studies (GWAS) in European or …

Genotype imputation for genome-wide association studies

J Marchini, B Howie - Nature Reviews Genetics, 2010 - nature.com
few years genome-wide association (GWA) studies have uncovered a large number of
convincingly replicated associations … of GWA studies to boost power, fine-map associations and …

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

AE Jaffe, RA Irizarry - Genome biology, 2014 - Springer
… (10 per group): between 1 and 5 years of age, between 30 and 40, greater than 60 years. …
(D) For the two samples highlighted with an arrow in (C), we show how a weighted average …

A tutorial on statistical methods for population association studies

DJ Balding - Nature reviews genetics, 2006 - nature.com
association studies have been with us for many years, even for the simplest analyses there
is little … Here I give an overview of statistical approaches to population association studies, …

Genome–wide association studies provide new insights into type 2 diabetes aetiology

TM Frayling - Nature Reviews Genetics, 2007 - nature.com
… The x axis gives the year that published evidence reached the levels of statistical confidence
that are now accepted as necessary for genetic association studies. CDKAL1, CDK5 …

Genomewide association studies and assessment of the risk of disease

TA Manolio - New England journal of medicine, 2010 - Mass Medical Soc
… Although complex conditions have been referred to as the geneticist's nightmare, 3 in the
past 5 years genomewide association studies have identified SNPs implicating hundreds of …

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

A Buniello, JAL MacArthur, M Cerezo… - … acids research, 2019 - academic.oup.com
… GWAS data for ten years. In the last two years we have significantly extended the Catalog's
scope from manual extraction and curation of data from GWAS studies in papers to support …

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

NC Allen, S Bagade, MB McQueen, JPA Ioannidis… - Nature …, 2008 - nature.com
… sizes studied per publication have steadily increased over the past 10 years, averaging 6
and 660, respectively, from 2003 to 2006, as compared to 2 and 380 between 1997 and 2002. …