Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective

P Moyaert, BE Padrela, CA Morgan, J Petr… - Frontiers in aging …, 2023 - frontiersin.org
The blood-brain barrier (BBB) consists of specialized cells that tightly regulate the in- and
outflow of molecules from the blood to brain parenchyma, protecting the brain’s …

Bloodbrain barrier dysfunction in brain diseases: Clinical experience

K Schoknecht, H Shalev - Epilepsia, 2012 - Wiley Online Library
bloodbrain barrier dysfunction are diverse and may range from physical endothelial damage
in traumatic brain injury … Clinically, bloodbrain barrier dysfunction is often detected using …

Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview

SR Archie, A Al Shoyaib, L Cucullo - Pharmaceutics, 2021 - mdpi.com
… The blood-brain barrier (BBB) is a fundamental component of the central nervous system (…
Thus, the enzymatic blood-brain barrier protects the brain from circulating neurotransmitters …

The bloodbrain barrier: an overview: structure, regulation, and clinical implications

P Ballabh, A Braun, M Nedergaard - Neurobiology of disease, 2004 - Elsevier
… The bloodbrain barrier (BBB) is a diffusion barrier essential for the normal function of the
central nervous system. The BBB endothelial cells differ from endothelial cells in the rest of the …

The role of the blood brain barrier in neurodegenerative disorders and their treatment

AM Palmer - Journal of Alzheimer's Disease, 2011 - content.iospress.com
… This review will consider brain disorders and the progress and prospects made in
discovering medicines to treat them, with particular emphasis on the role of the BBB in both …

[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
… their susceptibility to barrier leakage based … barrier dysfunction in clinical and postmortem
studies, summarize changes that lead to barrier leakage in patients and highlight the clinical

The bloodbrain barrier and immune function and dysfunction

WA Banks, MA Erickson - Neurobiology of disease, 2010 - Elsevier
The bloodbrain barrier (BBB) is the monocellular interface that divides the peripheral
circulation from direct contact with the central nervous system (CNS). This interface consists of …

The bloodbrain barrier in neurodegenerative disease: a rhetorical perspective

PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
barrier play a role in normal brain function as well. Moreover, we tend to view the barrier
dysfunction … However, as alluded to before and discussed in greater detail next, a binary view as …

Bloodbrain barrier: Recent developments and clinical correlations

EE Benarroch - Neurology, 2012 - AAN Enterprises
… The bloodbrain barrier (BBB) is a dynamic component of this unit and is a key interface for
molecular exchange between the blood and the brain interstitial fluid. The endothelial cells …

Dysfunction of the blood-brain barrier—a key step in neurodegeneration and dementia

CR Noe, M Noe-Letschnig, P Handschuh… - Frontiers in aging …, 2020 - frontiersin.org
… We hypothesize that a dysfunctional blood-brain might trigger apoptotic processes also
by preventing adequate availability of methyl groups, required both for the biosynthesis of …