Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

Y Que, C Hu, K Wan, P Hu, R Wang, J Luo… - International reviews …, 2022 - Taylor & Francis
… shown to be effective in patients with cytokine storm syndromes [Citation66], and further …
alternative for the treatment of cytokine release syndrome in patients with COVID-19 [Citation67]. …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
cytokine storms play an important role in severe COVID-19 cases. Therefore, neutralising
key … factors in cytokine release syndrome (CRS) will be of great value in reducing mortality in …

Cytokine release syndrome: inhibition of pro-inflammatory cytokines as a solution for reducing COVID-19 mortality

N Moradian, M Gouravani, MA Salehi, A Heidari… - European cytokine …, 2020 - Springer
… (ARDS), had higher levels of inflammatory cytokines. The … like COVID-19, is described as
cytokine release syndrome (CRS… an increased level of cytokines that are released from myeloid …

Biomarkers of cytokine release syndrome predict disease severity and mortality from COVID-19 in kidney transplant recipients

I Benotmane, P Perrin, GG Vargas, X Bassand… - …, 2021 - journals.lww.com
… The 30-day mortalitydisease and mortality. Viral load did not have prognostic significance
in our sample, suggesting that outcomes were chiefly driven by a cytokine release syndrome (…

Cytokine release syndrome in severe COVID-19

JB Moore, CH June - Science, 2020 - science.org
… antagonist is considered as an immunosuppressant which impairs the immune response
to the infection and possibly increases mortality in the late stage of patients with COVID-19.…

Tocilizumab treatment for cytokine release syndrome in hospitalized patients with coronavirus disease 2019: survival and clinical outcomes

CC Price, FL Altice, Y Shyr, A Koff, L Pischel, G Goshua… - Chest, 2020 - Elsevier
… It was selected for its scientific pathophysiologic plausibility and potential utility in treating
CRS (including in COVID-19 patients), increased morbidity and mortality using glucocorticoids …

Biomarkers of cardiac stress and cytokine release syndrome in COVID-19: A review

JS Gordon, MH Drazner - Current heart failure reports, 2021 - Springer
… with ACovCS and cytokine release syndrome in COVID-19, with a … associated with mortality
and critically ill pneumonia in COVID-19: … with increased mortality in patients with COVID-19. …

The effect of tocilizumab on cytokine release syndrome in COVID-19 patients

C de Caceres, R Martinez, P Bachiller, L Marin… - Pharmacological …, 2020 - Springer
… study was aimed to assess the efficacy and safety of tocilizumab (TCZ) and to investigate
the factors related to the progress and mortality of patients with a secondary cytokine release

[HTML][HTML] Laboratory parameters predicting mortality of adult in-patients with COVID-19 associated cytokine release syndrome treated with high-dose tocilizumab

B Lakatos, BG Szabo, I Bobek, L Gopcsa… - Acta Microbiologica et …, 2021 - akjournals.com
… Large randomized clinical trials in severe Coronavirus Disease 2019 (COVID-19mortality
of patients with tocilizumab administration in COVID-19 associated cytokine release syndrome

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
… For future epidemic preparedness and to reduce mortality in COVID-19 patients, global
effort is needed to promote novel therapy to treat virus-induced CRS during the …