Cytokine release syndrome in severe COVID-19

JB Moore, CH June - Science, 2020 - science.org
… signaling and this way potentially prevent or mitigate Acute Respiratory Distress Syndrome
(ARDS) COVID-19 patients. Compared to the monoclonal antibodies, tocilizumab, sarilumab, …

Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

Y Que, C Hu, K Wan, P Hu, R Wang, J Luo… - International reviews …, 2022 - Taylor & Francis
… has been shown to be effective in patients with cytokine storm syndromes [Citation66],
and … for the treatment of cytokine release syndrome in patients with COVID-19 [Citation67]. …

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
cytokine storms play an important role in severe COVID-19 … key inflammatory factors in
cytokine release syndrome (CRS) … critically ill COVID-19 patients with significantly elevated IL-6. …

Cytokine release syndrome‐associated encephalopathy in patients with COVID19

P Perrin, N Collongues, S Baloglu… - European Journal of …, 2021 - Wiley Online Library
… describe the neurological manifestations of patients with COVID-19 and to gain … COVID-19
symptom onset (D0). Red stars denote the days on which levels of cytokine release syndrome-…

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
… In COVID-19 patients with elevated inflammatory cytokines, postmortem pathology has
revealed tissue necrosis and interstitial macrophage and monocyte infiltrations in the lung, heart …

Definition and risks of cytokine release syndrome in 11 critically ill COVID-19 patients with pneumonia: analysis of disease characteristics

W Wang, X Liu, S Wu, S Chen, Y Li… - The Journal of …, 2020 - academic.oup.com
… According to the results of monitoring (the date of transfer out of the ICU), the final follow-up
date was 18 February 2020 for all COVID-19 patients participating in this study. Study of this …

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity

A Picchianti Diamanti, MM Rosado, C Pioli… - International journal of …, 2020 - mdpi.com
… reported a role for IL-6 and IL-10 in monitoring COVID-19 patients. In particular, significantly
higher levels of IL-6 and IL-10 have been identified in severe COVID-19 patients than in the …

Therapeutics for the management of cytokine release syndrome in COVID-19

S Ghosh, S Durgvanshi, SS Han… - Current topics in …, 2023 - ingentaconnect.com
… , several drugs are under trials to control the cytokine storm. In this review, we … of cytokine
storms in COVID-19 patients. Hitherto, several promising candidates such as IL-1 and IL-6

Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy

R Hong, H Zhao, Y Wang, Y Chen, H Cai… - Bone marrow …, 2021 - nature.com
… may experience a shorter duration of CRS than COVID-19 patients, the lack of a significant
difference in our findings might be related to the small sample sizes and different treatment …

The definition and risks of cytokine release syndrome-like in 11 covid-19-infected pneumonia critically ill patients: Disease characteristics and retrospective analysis

W Wenjun, L Xiaoqing, W Sipei, L Puyi, H Liyan… - MedRxiv, 2020 - medrxiv.org
patients infected with COVID-19, we defined and identified eight patients (72.7%) with cytokine
release syndrome… increase of IL-6 in peripheral blood was the highest risk factor of CRSL. …