Clinical Manifestations of Cytokine Storm and Immune Response to COVID-19: Literature Review

S Kowsarnia - Open Journal of Internal Medicine, 2021 - research.sdpublishers.net
… around the globe, the primary determinant of mortality is age. … As a result, the production of
cytokines and chemokines such … , causes overexpression of cytokines and chemokines that …

The possible role of vitamin D in suppressing cytokine storm and associated mortality in COVID-19 patients

A Daneshkhah, V Agrawal, A Eshein, H Subramanian… - MedRxiv, 2020 - medrxiv.org
… to bioactivity of IL-6 and production of cytokine storm plays a role in COVID-19 complications
affecting the A-CMR across different countries. Clinical data on cytokine levels in COVID-19 …

Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity

S Maity, A Santra, AV Hebbani, S Pulakuntla… - Gene, 2023 - Elsevier
Cytokine storm in patients with severe symptoms is understood to be characterized by enhanced
serum levels of many cytokines … of treating cytokine storm within the critical period (5 to …

Critically Ill Coronavirus Disease 2019 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection

A Arcanjo, K Guimarães Pinto, J Logullo… - The Journal of …, 2021 - academic.oup.com
… The cytokine storm syndrome is most commonly triggered by … the development of the cytokine
storm consist of a different … in inducing the cytokine storm in critically ill patients with COVID-…

Vandetanib blocks the cytokine storm in SARS-CoV-2-infected mice

AC Puhl, GF Gomes, S Damasceno, EJ Fritch… - ACS …, 2022 - ACS Publications
… Studies have revealed higher levels of cytokine storm associated with more severe COVID-19
development. (12) In these patients, the inflammatory substances from the cytokine storm

Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections …

SM Keating, JW Heitman, S Wu, X Deng… - Journal of …, 2016 - Am Soc Microbiol
… significant insight into critical events occurring during this time. Cytokines, chemokines, and
… infections identified here may be important determinants of the subsequent disease course. …

Longitudinal cytokine profile in patients with mild to critical COVID-19

L Ling, Z Chen, G Lui, CK Wong, WT Wong… - Frontiers in …, 2021 - frontiersin.org
… early and late cytokine profiles in patients with mild, moderate, and severe/critical COVID-19.
The secondary objective was to measure the associations between cytokines and length of …

Deciphering the balance of IL-6/IL-10 cytokines in severe to critical COVID-19 patients

MB Azaiz, AB Jemaa, W Sellami, C Romdhani… - Immunobiology, 2022 - Elsevier
… response, a “Cytokine storm,” that involves both pro- and anti-inflammatory cytokines. In the
… status as represented by the levels of IL-6/IL-10 in severe to critical COVID-19 patients. 66 …

Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signaling

BK Gajjela, MM Zhou - Drug discovery today, 2022 - Elsevier
… a crucial determinant of virulence, acting to promote the overexpression of proinflammatory
… GM-CSF is a cytokine that is critical for healthy pulmonary function and is necessary for the …

… dots in emerging mast cell research: do factors affecting mast cell activation provide a missing link between adverse COVID-19 outcomes and the social determinants …

R da Silveira Gorman, IU Syed - Medical Sciences, 2022 - mdpi.com
… [65] suggest a range of potential drugs for treating COVID-19 cytokine storm including
mast cell stabilizing drugs, tryptase inhibitors, zinc-mediated inhibitors, and tryptase-specific …