Is a “cytokine storm” relevant to COVID-19?

P Sinha, MA Matthay, CS Calfee - JAMA internal medicine, 2020 - jamanetwork.com
… clearance of infectious agents. Cytokine storm implies that the levels of released cytokines
are … To add further complexity, most mediators implicated in cytokine storm demonstrate …

Deciphering the COVID19 cytokine storm: systematic review and meta‐analysis

R Mulchandani, T Lyngdoh… - European journal of …, 2021 - Wiley Online Library
cytokines and chemokines produced by a dysregulated immune response with subsequent
multi-organ failure. Interestingly, the COVID-19-associated cytokine stormCOVID-19 infection

[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
… In order to determine the presence and magnitude of functional immunosuppression during
COVID-19 infection, we quantitated IFN-ɣ– and TNF-α–producing cells in overnight cell …

Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 associated cytokine storm as the patients who are severely ill along with a high
concentration of pro-inflammatory cytokines. … therapy for infection-related cytokine storm are …

[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19

JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
… early stage of COVID-19 infection played a major role in the development of cytokine storm,
and various cytokines such as IL-6 and IL-1 were involved in severe COVID-19. Furthermore…

[HTML][HTML] The COVID-19 cytokine storm; what we know so far

D Ragab, H Salah Eldin, M Taeimah… - Frontiers in …, 2020 - frontiersin.org
COVID-19 infection is accompanied by an aggressive … pro-inflammatory cytokines in an event
known as “cytokine storm.” The … Several studies analyzing cytokine profiles from COVID-19

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
cytokine storm which occurs in COVID-19 infection. LF22-0542 (Safotibant) is a BKB1R
antagonist with promising anti-inflammatory results [126], [127]. Several clinical trials have been …

The pathogenesis and treatment of theCytokine Storm'in COVID-19

Q Ye, B Wang, J Mao - Journal of infection, 2020 - Elsevier
… deterioration of patients with COVID-19 infection and save the … infection induces cytokine
storm and the options to inhibit the … coronavirus infection causes an inflammatory cytokine storm

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

F Coperchini, L Chiovato, L Croce, F Magri… - Cytokine & growth factor …, 2020 - Elsevier
… in the cytokine storm related to SARS-CoV-2 infection. Basic and clinical evidences obtained
from previous SARS and MERS epidemics and available data from COVID-19 will be taken …

Preliminary predictive criteria for COVID-19 cytokine storm

R Caricchio, M Gallucci, C Dass, X Zhang… - Annals of the …, 2021 - ard.bmj.com
… occurring during COVID-19 infection, … COVID-19 storm. We also found that 43 out of 513
patients had an HScore of >169, but only 12 also met the clinical consensus of COVID-19 storm (…