The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
… of NLRP3 inflammasome activation, how dysregulation of NLRP3 inflammasome activation
causes disease, and potential therapeutics that inhibit NLRP3 inflammasome activation. …

NLRP3 inflammasome and inflammatory diseases

Z Wang, S Zhang, Y Xiao, W Zhang… - Oxidative medicine …, 2020 - Wiley Online Library
NLRP3 inflammasomes are of great importance to therapies targeting inflammation due
to their critical role in regulating inflammation. In many bacterial infections, pathogens …

Targeting the NLRP3 inflammasome in inflammatory diseases

MSJ Mangan, EJ Olhava, WR Roush… - Nature reviews Drug …, 2018 - nature.com
NLRP3 activation and regulation and highlight gaps in the understanding of activation
mechanisms. We discuss diseases in which overly active NLRP3 … are effective therapies in certain …

NLRP3 inflammasome in neurological diseases, from functions to therapies

L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
… with NLRP3 inflammasomeNLRP3 inflammasome signaling may represent a promising
therapeutic target for the treatment of neuroinflammation-associated neurological diseases

Neurodegenerative disease and the NLRP3 inflammasome

JA Holbrook, HH Jarosz-Griffiths, E Caseley… - Frontiers in …, 2021 - frontiersin.org
diseases. This review aims to summarise current literature on the role of the NLRP3
inflammasome in … Therapies targeting the NLRP3 inflammasome shouldn’t be disregarded for …

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
NLRP3 inflammasome and its crucial role in the pathology of neurodegenerative disorders,
such as Alzheimer's disease, Parkinson's disease, … target the NLRP3 inflammasome pathway …

Focus on the Role of NLRP3 Inflammasome in Diseases

R Fusco, R Siracusa, T Genovese… - International journal of …, 2020 - mdpi.com
… (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, … knowledge about the NLRP3
inflammasome role in these … and beneficial inflammasome so that new therapies can be …

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

E Ozaki, M Campbell, SL Doyle - Journal of inflammation research, 2015 - Taylor & Francis
… such as Alzheimer’s disease, atherosclerosis, metabolic … NLRP3 inflammasome complex
and its activation in disease, … We discuss the current therapies available and those under …

NLRP3 inflammasome, an immune‐inflammatory target in pathogenesis and treatment of cardiovascular diseases

Y Wang, X Liu, H Shi, Y Yu, Y Yu, M Li… - Clinical and …, 2020 - Wiley Online Library
… Thus, NLRP3 inflammasome is a key molecule involved in the pathogenesis of … NLRP3
inflammasome-based targeted therapies for CVDs and the clinical evaluation of these therapies

The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Ageing research reviews, 2020 - Elsevier
… regulatory mechanisms of the NLRP3 inflammasome in the pathogenic … NLRP3 inflammasome
for AD. Further clarification of the regulatory mechanisms of the NLRP3 inflammasome in …