… of the in vitro models and native animal models to the … of humanized animal models. A
description of the complete technological methodology involved in the generation of humanized or …

… model compounds and anticancer drugs, we demonstrated how these mouse lines can be
applied to predict drug-drug interactions in … trials and the personalized treatment of cancer. …

… studies cannot be conducted for ethical and practical reasons. Thus, humanized animal
models could … insight into the determinants of drug disposition and drug–drug interaction (DDI). …

… The humanized mouse models described in the present work might help to further
elucidate how this gene is regulated. However, it should be noted that the expression level of …

… Typical rodent models do not predict drug-drug interactions … In the current study, a PXR-humanized
mouse model was … In this PXR-humanized mouse model, PXR is selectively …

… There is currently considerable debate about possible drug-drug interactions resulting from
the inhibition of drug transporters. Although in vivo studies in humanized transporter mice …

… made on studies aiming … mouse model with a humanized liver that is made by iPS-derived
hu-hepatocytes and hu-immune cells. This development will provide researchers with a model …

… for an improved prediction of the pharmacokinetic, drug–drug interaction and safety
characteristics of compounds in humans. The specific advantages and disadvantages of these …

… clearance and pharmacokinetics, as well as in predicting potential drug-drug interactions …
of some humanized transgenic mouse models expressing human drug-metabolizing enzymes. …

… However, with use of available in vitro or in vivo animal models, it … drug development was
completed (Bode, 2010). Therefore, we investigated whether TK-NOG mice with humanized …