… of human OATP family members, the role of human OATPs in drug–drug interactions, and the
… of genetic variations in SLCO genes encoding OATP proteins are the focus of this chapter. …

… a F g ), the concentrations of coadministered drugs, and the hepatic elimination processes.
We applied this method to DDI studies involving various OATP substrates and estimated the …

… , and so this interaction might be caused by the inhibition of OATP1B1.We initially reported
… interactions with OATP1B1 substrates.We estimated that the AUC of OATP1B1 substrates …

… By extending the set of OATP1B1 substrates, we explored this unexpected strong substrate
dependence of the gemfibrozil inhibitory effect. Taurocholic acid, troglitazone sulfate, …

… Since several widely prescribed drugs have been identified as substrates for OATP1B1 (
Table 1 ), OATP1B1-mediated drug-drug interactions are in the focus of several studies. …

… clinically used drugs have been identified as substrates of OATP … OATP1B1 is involved in
the drug–drug interactions of cyclosporine, gemfibrozil and rifampicin with OATP1B1 substrates…

… Without referring to specific transporters, numerous widely prescribed classes of drugs are
included in the list of OATP substrates, such as 3-Hydroxy-3-methylglutaryl coenzyme A (HMG…

… on drug–drug interactions at the levels of small intestine, liver and kidney largely using the
examples of transporter substrates, … Besides being a substrate of OATP1B1, pravastatin and …

… OATP substrates as well as OATP1B1 interacting drugs to date (cf. refs 3,7), limited data is
available regarding OATP1B3 and OATP2B1 interacting drugs. … a substrate of all three OATPs …

… systemic exposure due to drug–drug interaction (DDI) on drug transporters as well as …
exhibit broad substrate selectivity like OATP1B1 and 1B3. Substrates drugs of these OATPs are …