… This review provides a comprehensive overview of the mechanisms underlying cytokine
storm, summarizes its pathophysiology and improves understanding of cytokine storm …

… This review enlightened the implications and risk factor of hypercytokinemia/cytokine storm
for COVID-19 patients, with special emphasis on potential therapeutic strategies used to …

… respiratory syndrome coronavirus 2” (SARSCoV-2) is yet to be enlightened further. Inflammatory
process along with the damage of the host’s immune system plays a pivotal role in all …

… ” refers to a scenario in which several cytokines released are harmful to the host [9, 38]. … of
an excessive cytokine storm [2]. It is worth noting that the production of numerous cytokines is …

… The hallmark of COVID-19 pathogenesis is the cytokine storm with elevated levels of
interleukin-6 (IL-6), IL-1β, tumor necrosis factor-alpha (TNF-α), chemokine (CC-motif) ligand 2 (…

… Alleviating overproduction of reactive oxygen species and cytokine storm in COVID-19 is …
, cytokine storm, hyperinflammation, and diminish the risk of organ failure. Direct antiviral roles …

The last 50 years have been marked by increased understanding of the underpinnings of
sepsis, its myriad manifestations and optimal approaches to therapy. The 50-year timeline that …

… The viral-provoked ACE2 downregulation aggravated a subsequent potentially lethal
cytokine storm. Both the tumor necrosis factor-alpha (TNF-α) receptor (TNFR), activated by the …

… system produces copious amounts of cytokines (ie, cytokine storm), which damages the …
edema, inflammation, hyper-proliferation, and cytokine storm together causing ARDS (Figure 4). …

… and the ability to contribute to the cytokine storm characteristic of COVID-19 (44). Aging is …
increase inflammatory responses leading to the cytokine storm for which the disease is …