… blood brain barrier (BBB) and neurodegeneration. The BBB tightly regulates the movement
of substances between the blood and the brain, … be used as an imaging marker for cSVD and …

… contrast-enhanced magnetic resonance imaging (DCE-MRI… blood–brain barrier (BBB) leaks
in the human brain during normal aging, in individuals with age-related cognitive dysfunction…

Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders,
including cerebral … An emerging biomarker of BBB dysfunction is BBB water exchange rate (k W …

… To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI to …

… Both DCE and DSC images were corrected for head displacement by aligning the images
to a volume image averaged over the precontrast DCE-MRI scans (FSL v5.0 ). In the following, …

… brain MR images from 124 aSAH patients imaged sequentially for over 6 months, to test
the potential of quantitative BBB imaging … The strength of our study is the use of imaging-based …

Purpose: Occurrence of brain damage is frequently associated with abnormal blood-brain
barrier (BBB) function. Two brain-specific proteins, S100β and neuron-specific enolase (NSE) …

… NIRF imaging permits the sensitive detection of fluorescent … imaging of animals. In this
study, we tested whether non-invasive detection of BBB impairment with planar NIRF imaging …

… Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early
biomarker of human cognitive dysfunction 7 , including the early clinical stages of Alzheimer’…

… Vascular cognitive impairment (VCI) is an important cause of … 5 Imaging and pathological
studies have shown white matter … initiates disruption of the blood–brain barrier (BBB) with …