Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

JR Wu, Y Hernandez, KF Miyasaki, EJ Kwon - Advanced drug delivery …, 2023 - Elsevier
bloodbrain barrier (BBB) is a highly regulated physical and functional boundary that tightly
controls the transport of materials between the blood and the brain. … of these imaging studies, …

Blood-brain barrier leakage in patients with early Alzheimer disease

HJ Van De Haar, S Burgmans, JFA Jansen… - Radiology, 2016 - pubs.rsna.org
Blood-brain barrier dysfunction as a cause and consequence of Alzheimer’s disease. J Cereb
BloodBlood-brain barrier impairment in dementia: current and future in vivo assessments. …

Imaging correlates of the bloodbrain barrier disruption in HIV-associated neurocognitive disorder and therapeutic implications

J Chaganti, K Marripudi, LP Staub, CD Rae, TM Gates… - Aids, 2019 - journals.lww.com
… HIV-associated neurocognitive disorders (HANDs) in the context of suppressive combination
antiretroviral therapy (cART) still occur. We explored the role of bloodbrain barrier (BBB) …

[HTML][HTML] Discerning the role of blood brain barrier dysfunction in Alzheimer's disease

QQ Tao, RR Lin, YH Chen, ZY Wu - Aging and Disease, 2022 - ncbi.nlm.nih.gov
… AD is linked to blood brain barrier (BBB) dysfunction [2]. BBB dysfunction has been identified
… Similarly, another study performed PET imaging found elevated neutrophil infiltration in the …

Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging

S Bhaskar, F Tian, T Stoeger, W Kreyling… - Particle and fibre …, 2010 - Springer
… Finally, direct in vivo imaging of nanomaterials is an exciting recent field that … imaging and
monitoring of drug delivery, with an emphasis on most recently introduced molecular imaging

Microvascular dysfunction in blood-brain barrier disruption and hypoperfusion within the infarct posttreatment are associated with cerebral edema

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, TY Wu… - Stroke, 2022 - Am Heart Assoc
… perfusion weighted imaging (DSC-PWI) image. The follow-up … the cerebral blood flow (CBF)
map and blood-brain barrier (… and method for blood brain permeability imaging (bbpi) US …

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

VV Senatorov Jr, AR Friedman, DZ Milikovsky… - Science Translational …, 2019 - science.org
… (A) Representative images from immunofluorescence-stained brain sections used to … (B)
Representative image from a brain section of an 18-month-old mouse immunostained to …

Optical imaging to map blood-brain barrier leakage

H Jaffer, IM Adjei, V Labhasetwar - Scientific reports, 2013 - nature.com
… Vascular leakage in the brain is a major complication associated with brain injuries and …
to disruption of the blood-brain barrier (BBB). We have developed an optical imaging method, …

Bloodbrain barrier dysfunction as a hallmark pathology in chronic traumatic encephalopathy

CP Doherty, E O'Keefe, E Wallace… - … of Neuropathology & …, 2016 - academic.oup.com
… Here, we provide evidence that the bloodbrain barrier (BBB) is disrupted in regions of … in
the brain of a patient with PSP. This report represents the first description of BBB dysfunction in …

Bloodbrain barrier permeability and long-term clinical and imaging outcomes in cerebral small vessel disease

JM Wardlaw, FN Doubal, M Valdes-Hernandez… - Stroke, 2013 - Am Heart Assoc
… magnetic resonance, diffusion-weighted imaging (DWI) shows the … Bloodbrain barrier
imaging 6 weeks later: FLAIR 30 minutes … B, FLAIR and T2* images 2 years later show increased …