[HTML][HTML] Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

D Lo Tartaro, A Neroni, A Paolini, R Borella… - Communications …, 2022 - nature.com
… relevant immune changes in 31 aged patients with severe SARS-CoV-2 infection (mean
age: 76.4 years), compared to 33 adult patients at the same stage of infection (mean age: 49.8 …

Does patient age influence anti-cancer immunity?

G Pawelec - Seminars in immunopathology, 2019 - Springer
patients treated with anti-CTLA-4 or anti-PD-1/PD-L1 antibodies. Here, I briefly contrast immune
features of … ,” and the influence of patient age on the outcome of checkpoint blockade. As …

The effect of age on the clinical and immune characteristics of critically ill patients with COVID-19: A preliminary report

C Hu, J Li, X Xing, J Gao, S Zhao, L Xing - PLoS One, 2021 - journals.plos.org
features of severe and critically ill COVID-19 patients between the nonelderly (age < 60 years
old) and elderly (age … critically ill patients were male, while 68.4% of male patients were 60 …

Age-related changes in immune function: effect on airway inflammation

PJ Busse, SK Mathur - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
… in the immune system with age, specifically targeting those that might influence asthma (Table
I). There are several features that … Patients older than 55 years of age with asthma (n = 14) …

Age‐related remodelling of the blood immunological portrait and the local tumor immune response in patients with luminal breast cancer

L Berben, G Floris, C Kenis, B Dalmasso… - Clinical & …, 2020 - Wiley Online Library
… /senescence markers in blood, in order (i) to investigate the impact of ageing on systemic
immunity features (immunosenescence) in patients with luminal BC and (ii) to explore …

Age‐related differences in the immune response could contribute to determine the spectrum of severity of COVID‐19

G Costagliola, E Spada… - Immunity, inflammation …, 2021 - Wiley Online Library
… in severe patients with COVID-19 shows common features with … the ineffective immune
response in aged patients is associated … aged patients are more prone to develop an uncontrolled …

Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts

SA Weiss, J Han, F Darvishian, J Tchack… - Journal of translational …, 2016 - Springer
… We tested the hypothesis that age impacts the host anti-tumor immune response, … at time
of melanoma diagnosis on clinicopathologic features, the anti-tumor immune response as …

Older and younger patients treated with immune checkpoint inhibitors have similar outcomes in real-life setting

P Corbaux, D Maillet, A Boespflug… - European Journal of …, 2019 - Elsevier
Age-related immune dysfunction might impair the efficacy of immune checkpoint inhibitors
(ICIs) in older patients. We aimed to evaluate the impact of age on clinical outcomes and …

Evaluation of age-dependent immune signatures in patients with multiple sclerosis

M Eschborn, M Pawlitzki, T Wirth, C Nelke… - Neurology …, 2021 - AAN Enterprises
… in patients with MS. CD226 expression correlated with disability in younger (≤50 years)
patients with MS. CSF analysis revealed a significant age-dependent decline in various immune

Comprehensive transcriptome profiling in elderly cancer patients reveals aging‐altered immune cells and immune checkpoints

Y Wu, J Wei, X Chen, Y Qin, R Mao… - … Journal of Cancer, 2019 - Wiley Online Library
… To better understand the molecular features, we attempted to look at the different molecules
… Interestingly, more immune checkpoints are positively correlated with the age, where aging …