A 21st century evil: immunopathology and new therapies of COVID-19

TF Silva, F Tomiotto-Pellissier, RA Sanfelice… - Frontiers in …, 2020 - frontiersin.org
… in the lungs, and cytokine storms, which may contribute to its … previously approved drugs
and immunotherapy. In this context… , immunotherapy seems to be a possibly effective option to …

Sepsis, cytokine storms, and immunopathology: the divide between neonates and adults

KG Greenfield, VP Badovinac, TS Griffith… - …, 2021 - journals.aai.org
… a therapeutic option for adult … cytokines and chemokines partially overlap during the initial
stage of sepsis (2), resulting in a considerable amount of indecision on what immunotherapy in …

Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications

R Hirawat, MA Saifi, C Godugu - Life sciences, 2021 - Elsevier
cytokine storm is not new; it has garnered the attention primarily due to its striking role in
COVID-19. It is a race against time with containment the only option … the cytokine storm observed …

Role of PKM2-mediated immunometabolic reprogramming on development of cytokine storm

Z Liu, Y Le, H Chen, J Zhu, D Lu - Frontiers in immunology, 2021 - frontiersin.org
… is the leading cause of death in many inflammatory diseases, effective therapy options for
treating cytokine storm storms have not been fully explored. A previous study reported that …

COVID-19: more than a cytokine storm

G Riva, V Nasillo, E Tagliafico, T Trenti, P Comoli… - Critical care, 2020 - Springer
… of protective T cell immunity, while suppressing the emergent cytokine storm [7,8,9]. In fact, …
targeted immunotherapeutic drugs. During the last few years, cancer immunotherapy with …

Targeting macrophages as a therapeutic option in coronavirus disease 2019

M Gracia-Hernandez, EM Sotomayor… - Frontiers in …, 2020 - frontiersin.org
… , including cytokine storm, tissue damage, and fibrosis (Figure 2). If M1-like function is
altered, excessive secretion of pro-inflammatory cytokines can lead to a “cytokine storm” that …

[HTML][HTML] Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

G Suntharalingam, MR Perry, S Ward… - … England Journal of …, 2006 - Mass Medical Soc
… Lymphopenia has been observed as part of the cytokine storm … T-cell agonist drug rather
than to the cytokine storm alone. … and 6), and consisted of the cytokine storm, involving the rapid …

COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
… by elevated levels of pro-inflammatory cytokines, referred to as cytokine storm. Interleukins,
such as … Cytokine storm is defined as acute overproduction and uncontrolled release of pro-…

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states that share
the underpinnings of persistent immune cell activation and uninhibited cytokinecytokines. …

Cytokine storms, evolution and COVID-19

J Alcock, A Masters - Evolution, medicine, and public health, 2021 - academic.oup.com
… calming a cytokine storm, a dangerous immune overreaction to the infection. Treating cytokine
storms has … We explain why cytokine storms should be rare, and what special evolutionary …