SE Boyden, LM Kunkel - PLoS One, 2010 - journals.plos.org
… To map the loci conferring a survival advantage, we performed the second genomewide linkage scan on humanlongevity and the first using a high-density marker panel of single …
Q Tan, TA Kruse, K Christensen - Ageing research reviews, 2006 - Elsevier
… are enabling us to conduct genome-wide association and linkageanalyses in search of genes that modulate human ageing and longevity. Meanwhile, with the fast growing functional …
… In this respect, we are combining the molecular epidemiological studies in humanlongevity with cell biological approaches (figure 2). Especially when performing such analyses in the …
… (GWAS) of parental longevity in European descent UK Biobank … The results suggest that humanlongevity is highly polygenic … There may also be gender specific routes to longevity. …
Q Tan, JH Zhao, I Iachine, J Hjelmborg… - … Official Publication of …, 2004 - Wiley Online Library
… non-parametric linkageanalysis of affected sib-pairs (ASP) [Kruglyak and Lander, 1995: Am J Hum Genet 57:439–454] to localize genes that contribute to humanlongevity using long…
… of linkageanalysis to identify deleterious variants, whereas efficiency for identification of longevity … In this paper, we derived models for longevity and for the part on linkageanalysis we …
… To investigate further the potential links of HGPS, LMNA, and progerin … humanlongevity. Toward this end, we tested variants of the LMNA gene for association with extreme longevity in …
T Perls, LM Kunkel, AA Puca - Journal of the American …, 2002 - Wiley Online Library
… their role in humanlongevity merits further study. Centenarian sibships and possibly families highly clustered for exceptional longevity may prove to be helpful in discovering longevity-…
AA Puca, MJ Daly, SJ Brewster… - Proceedings of the …, 2001 - National Acad Sciences
… Therefore, multipoint genome-wide affected-only parametric linkageanalyses were conducted by using the allegro program under both a dominant and recessive model with reduced …