… Introduction: The continual Middle East respiratory syndrome (MERS) threat highlights the …
treat MERS coronavirus (MERS-CoV) infection. A surface spike (S) protein guides MERS-CoV …

… The MERS-CoV spike (S) protein is an … of the S protein in the MERS-CoV life cycle, summarize
recent advances in the development of vaccines and therapeutics based on the S protein, …

… mortality rate in humans, no vaccines have been approved to prevent MERS-CoV infection
in humans. MERS-CoV spike (S) protein is a key target for development of MERS vaccines. …

… MERS-CoV infection. Here we discuss the most recent studies on the structure of … MERS-CoV
spike protein and its role in virus binding and entry, and the development of MERS-CoV …

… , that SARS-CoV-2 and SARS-CoV use different ends/regions in S protein receptor-binding
motif … This review comprehensively addresses in detail the variations in S protein, its receptor-…

… Figure 1Severe acute respiratory syndrome coronavirus (SARS-CoV) spike features. (A)
Schematic representation of the SARS-CoV spike protein (S). The individual components of S …

… novel antiviral strategies to combat MERS. The MERS-CoV spike protein (MERS-S) is inserted
into the viral envelope and mediates viral entry into target cells. For this, MERS-S binds to …

… To improve the expression and conformational homogeneity of the prefusion MERS-CoV S
protein ectodomain we engineered variants based upon our previously determined structure …

… halt the spread of MERS-CoV. Here, we show that a recombinant protein containing a 212-…
(RBD: residues 367–606) of MERS-CoV spike (S) protein fused with human IgG Fc fragment (…

… MERS-CoV spike protein. These antibodies belong to six distinct epitope groups and interfere
with the three critical entry functions of the MERS-CoV spike protein… from lethal MERS-CoV …