Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome

S Mahajan, CE Decker, Z Yang, D Veis, ED Mellins… - Journal of …, 2019 - Elsevier
… and inflammatory cytokine levels in two CSS mouse models, one dependent on T cells and
… We further demonstrate that activation of Plcγ2 in myeloid cells controls CSS development …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been … Cytokine storms (CSs) are associated
with various pathologies, … cytokine release and cell death pathways; certain cytokines, …

In the eye of the COVID-19 cytokine storm

N Vaninov - Nature Reviews Immunology, 2020 - nature.com
syndrome (ARDS) and robust cytokine storm are the hallmark of severe COVID-19 cases.
Using single-cell … strategies that target the myeloid cell compartment, such as IL-6 inhibitors, to …

Myeloid autophagy genes protect mice against fatal TNF-and LPS-induced cytokine storm syndromes

YT Wang, A Sansone, A Smirnov, CL Stallings… - Autophagy, 2023 - Taylor & Francis
… in myeloid cells have been implicated in protecting mice in models of cytokine storm syndromes
(CSS), a more extensive genetic analysis of the autophagy pathway for this disorder has …

Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
… stimulation and hypersecretion of proinflammatory cytokines by neoplastic cells (50). … A
study of patients with acute myeloid leukemia undergoing induction chemotherapy found that …

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
… Instead, CpG DNA–induced MAS appears to be more dependent on myeloid cells. The
excess production of IFN-γ is dependent on IL-12 primarily produced by inflammatory monocytes …

Dysregulation of lung myeloid cells in COVID-19

B Salomé, A Magen - Nature Reviews Immunology, 2020 - nature.com
myeloid cells in COVID-19 Acute respiratory distress syndrome (ARDS) and robust cytokine
storm … Using single-cell RNA sequencing of bronchoalveolar lavage fluid, this preprint study …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
… on T- and NK-cell hyperactivation and production of … myeloid cells to promote histiocytosis,
cytokine storm, and life-threatening systemic immunopathology. BiTE, Bispecific T-cell

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
… , tissue damage, and acute respiratory distress syndrome. Here, we discuss the sensing of …
epithelial cells and circulating myeloid cells to release several pro-inflammatory cytokines [8, 9…

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… widely referred to as cytokine release syndrome (CRS) or, in particularly severe courses,
cytokine storm (CS)… (MDSC), members of a heterogeneous immature myeloid cell population, in …