C Funk - Expert opinion on drug metabolism & toxicology, 2008 - Taylor & Francis
… Clinical pharmacokinetic studies indicated that the different SLCO1B1 haplotypes correlated with the pharmacokinetics of many statins studied, reducing hepatic uptake and efficacy …
T Terada, D Hira - Journal of gastroenterology, 2015 - Springer
… drug development and clinical practice. In this review, we selected some clinically important drugtransporters … pharmacokinetic, pathophysiological, and pharmacogenetic implications. …
A Jetter, GA Kullak-Ublick - Pharmacological research, 2020 - Elsevier
… that the impact of hepatic BCRP on the overall pharmacokinetics of BCRP substrates cannot … pharmacokinetics of drugs is probably much larger than at the canalicular side of liver cells. …
M Patel, KS Taskar… - The Journal of Clinical …, 2016 - Wiley Online Library
… hepatictransporters in pharmacokinetics and drug-drug interactions (DDIs). Special emphasis is placed on transporters … 1B3 emerged as important hepaticdrug uptake pathways, sites …
H Liu, J Sahi - The Journal of Clinical Pharmacology, 2016 - Wiley Online Library
… Recent years have seen great advances in our ability to predict transporter-mediated pharmacokinetics and drug interactions. Decision trees for determining when clinical …
K Yoshida, K Maeda, Y Sugiyama - Annual review of …, 2013 - annualreviews.org
… transporters involved in the pharmacokinetics of … hepatic clearance from animals to humans. In vitro experimental systems used to evaluate the functions of membrane transporters are …
… This paper reviews the pharmacokinetic principles that govern the kinetics of uptake transporter … for assessing hepaticdrug clearance and the impact of drug−drug interactions (DDIs). …
L Liu, KS Pang - Drug metabolism and disposition, 2005 - ASPET
… Several basolateral transporters are present to conduct transport of organic anions, cations, and bile acids into the liver. In the past, our laboratory has utilized pharmacokinetic …
S Shugarts, LZ Benet - Pharmaceutical research, 2009 - Springer
… the influence intestinal and hepaticdrugtransporters have on pharmacokinetic parameters, … dosed drugs. This review also describes in detail the Biopharmaceutics Drug Disposition …