Hyperinflammation is a key component of severe COVID-19, residing underneath the
cytokine storm umbrella term, associated with poor outcomes. Better understanding of the …

COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes
only mild symptoms in the majority of the cases, while immunologic complications such as …

The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome
(COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS …

As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been con firmed in 125
048 people worldwide, carrying a mortality of approximately 3· 7%, 1 compared with a …

Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …

Objective Infection with the novel coronavirus SARS–CoV‐2 triggers severe illness with high
mortality in a subgroup of patients. Such a critical course of COVID‐19 is thought to be …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that is
responsible for coronavirus disease 2019 (COVID-19), which has rapidly spread across the …

The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China,
introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific …

Background A subset of patients with COVID-19 develops a hyperinflammatory syndrome
that has similarities with other hyperinflammatory disorders. However, clinical criteria …

Hemophagocytic syndrome (HPS) or hemophagocytic lymphohistiocytosis (HLH) is an acute
and rapidly progressive systemic inflammatory disorder characterized by cytopenia …