COVID-19: imbalanced cell-mediated immune response drives to immunopathology

J Wang, Q Li, YW Qiu, H Lu - Emerging Microbes & Infections, 2022 - Taylor & Francis
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an imminent threat to humanity …

COVID-19: imbalanced immune responses and potential immunotherapies

B Xie, J Zhang, Y Li, S Yuan, Y Shang - Frontiers in Immunology, 2021 - frontiersin.org
The ongoing pandemic coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading and has resulted in …

Dysregulated innate immune and inflammatory responses in SARS-CoV-2 infection and COVID-19 severity

P Ghosh, S Nagaraja, S Basavaraju… - Critical Reviews™ in …, 2021 - dl.begellhouse.com
Pathogenic coronaviruses (CoVs) have caused human respiratory infections and severe
disease outbreaks in the past two decades. Recent severe acute respiratory syndrome …

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …

COVID‐19 immunopathology: from acute diseases to chronic sequelae

M Arish, W Qian, H Narasimhan… - Journal of medical …, 2023 - Wiley Online Library
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis

PA Szabo, P Dogra, JI Gray, SB Wells, TJ Connors… - medRxiv, 2020 - medrxiv.org
Immune responses to respiratory viruses like SARS-CoV-2 originate and function in the
lung, yet assessments of human immunity are often limited to blood. Here, we conducted …

COVID-19: The emerging immunopathological determinants for recovery or death

T Ahmad, R Chaudhuri, MC Joshi… - Frontiers in …, 2020 - frontiersin.org
Hyperactivation of the host immune system during infection by SARS-CoV-2 is the leading
cause of death in COVID-19 patients. It is also evident that patients who develop …

COVID-19: immunology, immunopathogenesis and potential therapies

A Bhardwaj, L Sapra, C Saini, Z Azam… - International reviews …, 2022 - Taylor & Francis
Abstract The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and
affected millions of people around the globe. As of January 2021, 100 million confirmed …

[HTML][HTML] Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction

SJ Rouhani, JA Trujillo, AR Pyzer, J Yu, J Fessler… - Research …, 2021 - ncbi.nlm.nih.gov
The mechanisms explaining progression to severe COVID-19 remain poorly understood. It
has been proposed that immune system dysregulation/over-stimulation may be implicated …

Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

A Shafqat, S Shafqat, SA Salameh, J Kashir… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which causes
coronavirus-19 (COVID-19), has caused significant morbidity and mortality globally. In …