Robust biomarkers of aging have been developed from DNA methylation in humans and
more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a …

Epigenetic clocks for mice were generated based on deep-sequencing analysis of the
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …

Age-associated DNA methylation reflects aspect of biological aging—therefore epigenetic
clocks for mice can elucidate how the aging process in this model organism is affected by …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …

Aging is associated with dramatic changes to DNA methylation (DNAm), although the
causes and consequences of such alterations are unknown. Our ability to experimentally …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …