Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a
consequence display a radically altered phenotype that is thought to impair tissue function …

The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …

Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead.
They noted sustained cell-cycle arrest after repeated subculturing of human primary cells …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …