The mechanisms of human inheritance are such that if SNPs are in close physical proximity
(typically, 50 kb apart or closer) they are more likely than those that lie farther apart to have …

Genomewide Association Studies and Human Disease | NEJM Skip to main content NEJM
Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …

Human geneticists seek to understand the inherited basis of human biology and disease,
aiming either to gain insights that could eventually improve treatment or to produce useful …

Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …

When the time came to decide on the topic for the next in the series of Human Molecular
Genetics reviews, on this occasion, there was little need for debate. The advent of genome …

Genome-wide association studies have successfully identified numerous loci at which
common variants influence disease risk or quantitative traits. Despite these successes, the …

Following the identification of several disease-associated polymorphisms by genome-wide
association (GWA) analysis, interest is now focusing on the detection of effects that, owing to …

Genome-wide association studies (GWAS) have led to a rapid increase in available data on
common genetic variants and phenotypes and numerous discoveries of new loci associated …

Most common diseases and quantitative traits are heritable: determined in part by genetic
variation within the population. The inheritance is typically polygenic in that combined effects …

Genetic association studies are used to find candidate genes or genome regions that
contribute to a specific disease by testing for a correlation between disease status and …