TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
FL Mabrey, ED Morrell, MM Wurfel - Innate immunity, 2021 - journals.sagepub.com
COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within
the innate immune system drive the balance between deleterious inflammation and viral …
the innate immune system drive the balance between deleterious inflammation and viral …
SARS-CoV-2 takes its Toll
A Sariol, S Perlman - Nature immunology, 2021 - nature.com
SARS-CoV-2 takes its Toll | Nature Immunology Skip to main content Thank you for visiting
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TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection
RM van der Sluis, LB Cham, A Gris‐Oliver… - The EMBO …, 2022 - embopress.org
Understanding the molecular pathways driving the acute antiviral and inflammatory
response to SARS‐CoV‐2 infection is critical for developing treatments for severe COVID …
response to SARS‐CoV‐2 infection is critical for developing treatments for severe COVID …
TLRs: innate immune sentries against SARS-CoV-2 infection
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …
SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19
S Sahanic, R Hilbe, C Dünser, P Tymoszuk… - Heliyon, 2023 - cell.com
Abstract Background Toll-like receptors (TLRs) play a pivotal role in the immunologic
response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
The innate immune response is critical for recognizing and controlling infections through the
release of cytokines and chemokines. However, severe pathology during some infections …
release of cytokines and chemokines. However, severe pathology during some infections …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
COVID-19–associated morbidity and mortality have been attributed to a pathologic host
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …
response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine …
Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathology
PRS Rodrigues, A Alrubayyi, E Pring… - Oxford open …, 2020 - academic.oup.com
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a global health crisis and will …
respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a global health crisis and will …