[HTML][HTML] Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species
Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …
[HTML][HTML] Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …
[HTML][HTML] Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment
Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …
as a type of molecular clock. This clock can be hastened by conditions that decrease …
[HTML][HTML] Multi-tissue DNA methylation age predictor in mouse
Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …
predictive of chronological and biological age. However, it is not known whether these …
Nature of epigenetic aging from a single-cell perspective
Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …
Epigenetic clock: just a convenient marker or an active driver of aging?
VV Ashapkin, LI Kutueva, BF Vanyushin - … studies in aging and anti-aging …, 2019 - Springer
A global DNA hypomethylation and local changes in the methylation levels of specific DNA
loci occur during aging in mammals. Global hypomethylation mainly affects highly …
loci occur during aging in mammals. Global hypomethylation mainly affects highly …
[HTML][HTML] Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
[HTML][HTML] Epigenetic clock and methylation studies in vervet monkeys
DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
Background DNA methylation is an epigenetic mark associated with the repression of gene
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
DNA methylation clocks for dogs and humans
DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …
epigenetic clocks, which predict chronological age with remarkable accuracy and show …